APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress
APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′ nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA damage response (DDR) pathway via ill-defined mechanisms. Here we report that APE2 resection activity is regulated by DNA interactions in its Zf-GRF domain, a region sharing h...
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Full title
APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5240719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5240719
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1610011114
