Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
About this item
Full title
Author / Creator
Deuis, Jennifer R. , Dekan, Zoltan , Wingerd, Joshua S. , Smith, Jennifer J. , Munasinghe, Nehan R. , Bhola, Rebecca F. , Imlach, Wendy L. , Herzig, Volker , Armstrong, David A. , Rosengren, K. Johan , Bosmans, Frank , Waxman, Stephen G. , Dib-Hajj, Sulayman D. , Escoubas, Pierre , Minett, Michael S. , Christie, Macdonald J. , King, Glenn F. , Alewood, Paul F. , Lewis, Richard J. , Wood, John N. and Vetter, Irina
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Human genetic studies have implicated the voltage-gated sodium channel Na
V
1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of the tarantula
Pamphobeteus nigricolor,
potently inhibits Na
V
1.7 (IC
50
0.9 nM) with at least 40–1000-fold selectivity over all othe...
Alternative Titles
Full title
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
Authors, Artists and Contributors
Author / Creator
Dekan, Zoltan
Wingerd, Joshua S.
Smith, Jennifer J.
Munasinghe, Nehan R.
Bhola, Rebecca F.
Imlach, Wendy L.
Herzig, Volker
Armstrong, David A.
Rosengren, K. Johan
Bosmans, Frank
Waxman, Stephen G.
Dib-Hajj, Sulayman D.
Escoubas, Pierre
Minett, Michael S.
Christie, Macdonald J.
King, Glenn F.
Alewood, Paul F.
Lewis, Richard J.
Wood, John N.
Vetter, Irina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5247677
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5247677
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep40883
