Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis
Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis
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Author / Creator
Chen, Xi , Cao, Xinwei , Sun, Xiaohua , Lei, Rong , Chen, Pengfei , Zhao, Yongxu , Jiang, Yuhang , Yin, Jie , Chen, Ran , Ye, Deji , Wang, Qi , Liu, Zhanjie , Liu, Sanhong , Cheng, Chunyan , Mao, Jie , Hou, Yingyong , Wang, Mingliang , Siebenlist, Ulrich , Eugene Chin, Y , Wang, Ying , Cao, Liu , Hu, Guohong and Zhang, Xiaoren
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Transforming growth factor beta (TGF
β
) signaling in breast cancer is selectively associated with pulmonary metastasis. However, the underlying mechanisms remain unclear. Here we show that Bcl-3, a member of the IκB family, serves as a critical regulator in TGF
β
signaling to modulate breast cancer pulmonary metastasis. Bcl-3 expressio...
Alternative Titles
Full title
Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5261001
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5261001
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2016.405
