p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA
p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA
About this item
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Author / Creator
Xu, L-Z , Li, S-S , Zhou, W , Kang, Z-J , Zhang, Q-X , Kamran, M , Xu, J , Liang, D-P , Wang, C-L , Hou, Z-J , Wan, X-B , Wang, H-J , Lam, E W-F , Zhao, Z-W and Liu, Q
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Aberrant p62 overexpression has been implicated in breast cancer development. Here, we found that p62 expression was elevated in breast cancer stem cells (BCSCs), including CD44
+
CD24
−
fractions, mammospheres, ALDH1
+
populations and side population cells. Indeed, short-hairpin RNA (shRNA)-mediated knockdown of p62 impaired brea...
Alternative Titles
Full title
p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5269535
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5269535
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/onc.2016.202
