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Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lym...

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lym...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278460

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

About this item

Full title

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.764-769

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA sequencing and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Δ778–786) generated by a focal deletion...

Alternative Titles

Full title

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278460

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5278460

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1608839114

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