ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Charles Roberts and colleagues show that deletion of
Arid1a
from mouse intestinal epithelium results in invasive adenocarcinomas resembling human colorectal cancer. They further show that ARID1A loss impairs SWI/SNF targeting and enhancer-mediated gene regulation.
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are...
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Full title
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5285448
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5285448
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3744
