Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
About this item
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Author / Creator
Tu, Zhuchi , Yang, Weili , Yan, Sen , Yin, An , Gao, Jinquan , Liu, Xudong , Zheng, Yinghui , Zheng, Jiezhao , Li, Zhujun , Yang, Su , Li, Shihua , Guo, Xiangyu and Li, Xiao-Jiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR/Cas9-mediated mosaic mutations...
Alternative Titles
Full title
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5290468
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5290468
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep42081
