Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS...
Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
We observed that the transient induction of mtDNA double strand breaks (DSBs) in cultured cells led to activation of cell cycle arrest proteins (p21/p53 pathway) and decreased cell growth, mediated through reactive oxygen species (ROS). To investigate this process
in vivo
we developed a mouse model where we could transiently induce mtDNA DSBs...
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Full title
Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5299712
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5299712
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2016.123
