A new approach to quantification of mAb aggregates using peptide affinity probes
A new approach to quantification of mAb aggregates using peptide affinity probes
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to a variety of adverse events in treatment. Here, we describe a proof-of-concept for new methodology to detect and quantify mAb aggregation. Assay development included using an aggregated mAb as bait for screening of...
Alternative Titles
Full title
A new approach to quantification of mAb aggregates using peptide affinity probes
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5301252
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5301252
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep42497
