Antibody Redesign by Chain Shuffling from Random Combinatorial Immunoglobulin Libraries
Antibody Redesign by Chain Shuffling from Random Combinatorial Immunoglobulin Libraries
About this item
Full title
Author / Creator
Kang, A S , Jones, T M and Burton, D R
Publisher
Washington, DC: National Academy of Sciences of the United States of America
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: National Academy of Sciences of the United States of America
Subjects
More information
Scope and Contents
Contents
A number of experiments on the shuffling of heavy and light chains from antibodies of defined specificity for the transition-state analogue hapten nitrophenyl phosphonamidate are described. The experiments report on the promiscuity of heavy and light chains in binding antigen and the feasibility of antibody redesign by this shuffling process. The c...
Alternative Titles
Full title
Antibody Redesign by Chain Shuffling from Random Combinatorial Immunoglobulin Libraries
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_53085
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_53085
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.88.24.11120
