Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
About this item
Full title
Author / Creator
Yauch, Robert L. , Dijkgraaf, Gerrit J. P. , Alicke, Bruno , Januario, Thomas , Ahn, Christina P. , Holcomb, Thomas , Pujara, Kanan , Stinson, Jeremy , Callahan, Christopher A. , Tang, Tracy , Bazan, J. Fernando , Kan, Zhengyan , Seshagiri, Somasekar , Hann, Christine L. , Gould, Stephen E. , Low, Jennifer A. , Rudin, Charles M. and de Sauvage, Frederic J.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that inhibits Hh signaling by targeting the serpentine receptor Smoothened (SMO), has produced promising anti-tumor responses in early clinical studies of cancers driven by mutations in th...
Alternative Titles
Full title
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Authors, Artists and Contributors
Author / Creator
Dijkgraaf, Gerrit J. P.
Alicke, Bruno
Januario, Thomas
Ahn, Christina P.
Holcomb, Thomas
Pujara, Kanan
Stinson, Jeremy
Callahan, Christopher A.
Tang, Tracy
Bazan, J. Fernando
Kan, Zhengyan
Seshagiri, Somasekar
Hann, Christine L.
Gould, Stephen E.
Low, Jennifer A.
Rudin, Charles M.
de Sauvage, Frederic J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5310713
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5310713
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1179386
