Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic stem cells and thereby contributes to the development of leukaemia.
A mutated microenvironment in leukaemia
Hereditary mutations in the tyrosine phosphatase SHP2 (encoded by
PTPN11
Alternative Titles
Full title
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5317374
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5317374
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature20131
