cGAS is essential for the antitumor effect of immune checkpoint blockade
cGAS is essential for the antitumor effect of immune checkpoint blockade
About this item
Full title
Author / Creator
Wang, Hua , Hu, Shuiqing , Chen, Xiang , Shi, Heping , Chen, Chuo , Sun, Lijun and Chen, Zhijian J.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses. cGAS catalyzes the synthesis of cGAMP, which functions as a second messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs) and other immune modulatory molecules. Here we show that cGAS is indispensable for the...
Alternative Titles
Full title
cGAS is essential for the antitumor effect of immune checkpoint blockade
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5320994
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5320994
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1621363114
