Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
About this item
Full title
Author / Creator
Ahn, Seungkirl , Kahsai, Alem W. , Pani, Biswaranjan , Wang, Qin-Ting , Zhao, Shuai , Wall, Alissa L. , Strachan, Ryan T. , Staus, Dean P. , Wingler, Laura M. , Sun, Lillian D. , Sinnaeve, Justine , Choi, Minjung , Cho, Ted , Xu, Thomas T. , Hansen, Gwenn M. , Burnett, Michael B. , Lamerdin, Jane E. , Bassoni, Daniel L. , Gavino, Bryant J. , Husemoen, Gitte , Olsen, Eva K. , Franch, Thomas , Costanzi, Stefano , Chen, Xin and Lefkowitz, Robert J.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The β₂-adrenergic receptor (β₂AR) has been a model system for understanding regulatory mechanisms of G-protein–coupled receptor (GPCR) actions and plays a significant role in cardiovascular and pulmonary diseases. Because all known β-adrenergic receptor drugs target the orthosteric binding site of the receptor, we set out to isolate allosteric liga...
Alternative Titles
Full title
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Authors, Artists and Contributors
Author / Creator
Kahsai, Alem W.
Pani, Biswaranjan
Wang, Qin-Ting
Zhao, Shuai
Wall, Alissa L.
Strachan, Ryan T.
Staus, Dean P.
Wingler, Laura M.
Sun, Lillian D.
Sinnaeve, Justine
Choi, Minjung
Cho, Ted
Xu, Thomas T.
Hansen, Gwenn M.
Burnett, Michael B.
Lamerdin, Jane E.
Bassoni, Daniel L.
Gavino, Bryant J.
Husemoen, Gitte
Olsen, Eva K.
Franch, Thomas
Costanzi, Stefano
Chen, Xin
Lefkowitz, Robert J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5321036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5321036
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1620645114
