DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degradation inducers for conformational or misfolded p53...
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Full title
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5340314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5340314
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3427
