Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
About this item
Full title
Author / Creator
Peres, Raphael S , Santos, Gabriela B , Cecilio, Nerry T , Jabor, Valquíria A P , Niehues, Michael , Torres, Bruna G S , Buqui, Gabriela , Silva, Carlos H T P , Costa, Teresa Dalla , Lopes, Norberto P , Nonato, Maria C , Ramalho, Fernando S , Louzada-Júnior, Paulo , Cunha, Thiago M , Cunha, Fernando Q , Emery, Flavio S and Alves-Filho, Jose C
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
Subjects
More information
Scope and Contents
Contents
The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refractory to LEF. Here, we investigated lapachol (LAP), a natural...
Alternative Titles
Full title
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
Authors, Artists and Contributors
Author / Creator
Santos, Gabriela B
Cecilio, Nerry T
Jabor, Valquíria A P
Niehues, Michael
Torres, Bruna G S
Buqui, Gabriela
Silva, Carlos H T P
Costa, Teresa Dalla
Lopes, Norberto P
Nonato, Maria C
Ramalho, Fernando S
Louzada-Júnior, Paulo
Cunha, Thiago M
Cunha, Fernando Q
Emery, Flavio S
Alves-Filho, Jose C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5341405
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5341405
Other Identifiers
ISSN
1478-6362,1478-6354
E-ISSN
1478-6362
DOI
10.1186/s13075-017-1236-x
