HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive kinase JNK constitutively associates with mTORC1 und...
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HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5341796
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5341796
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3335
