BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
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Author / Creator
Weber, Martin , Wu, Tiffany , Meilandt, William J. , Dominguez, Sara L. , Solanoy, Hilda O. , Maloney, Janice A. , Ngu, Hai , Baca, Miriam , Kung, Chung , Lima, Lisa , Earr, Timothy K. , Fleck, Daniel , Shields, Shannon D. , Forrest, William F. , Foreman, Oded , Warming, Søren , Watts, Ryan J. and Scearce-Levie, Kimberly
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Assessing BACE1 (β-site APP cleaving enzyme 1) knockout mice for general health and neurological function may be useful in predicting risks associated with prolonged pharmacological BACE1 inhibition, a treatment approach currently being developed for Alzheimer’s disease. To determine whether BACE1 deletion-associated effects in mice generalize to a...
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Full title
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5345047
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5345047
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep44249
