Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically...
Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Standard isotropic culture fails to recapitulate the spatiotemporal gradients present during native development. Cartilage grown from human mesenchymal stem cells (hMSCs) is poorly organized and unstable in vivo. We report that human cartilage with physiologic organization and in vivo stability can be grown in vitro from self-assembling hMSCs by im...
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Full title
Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5347558
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5347558
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1611771114
