Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emp...
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients
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Author / Creator
Shi, Jijing , Zhao, Juanjuan , Zhang, Xin , Cheng, Yongqian , Hu, Jinhua , Li, Yuanyuan , Zhao, Xin , Shang, Qinghua , Sun, Yanling , Tu, Bo , Shi, Lei , Gao, Bin , Wang, Fu-Sheng and Zhang, Zheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Natural killer (NK) cells can induce liver fibrosis remission by killing hepatic stellate cells (HSCs) and producing interferon (IFN)-γ in a mouse model; however, their anti-fibrotic immune-characteristics and regulatory mechanisms by HSCs remain to be determined, especially in livers from HBV-infected liver cirrhosis (LC) patients. We analyzed fre...
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Full title
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5349579
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5349579
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep44544
