The V Proteins of Paramyxoviruses Bind the IFN-Inducible RNA Helicase, mda-5, and Inhibit Its Activa...
The V Proteins of Paramyxoviruses Bind the IFN-Inducible RNA Helicase, mda-5, and Inhibit Its Activation of the IFN-β Promoter
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Most paramyxoviruses circumvent the IFN response by blocking IFN signaling and limiting the production of IFN by virus-infected cells. Here we report that the highly conserved cysteine-rich C-terminal domain of the V proteins of a wide variety of paramyxoviruses binds melanoma differentiation-associated gene 5 (mda-5) product. mda-5 is an IFN-induc...
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Full title
The V Proteins of Paramyxoviruses Bind the IFN-Inducible RNA Helicase, mda-5, and Inhibit Its Activation of the IFN-β Promoter
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_535396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_535396
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0407639101
