CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its trans...
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
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England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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(chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most commonly mutated genes in autism spectrum disorders (ASD) identified in exome-sequencing studies. Loss of function mutations in the gene have also been found in schizophrenia (SZ) and intellectu...
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Full title
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5357816
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5357816
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ISSN
2040-2392
E-ISSN
2040-2392
DOI
10.1186/s13229-017-0124-1
