A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS
A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant
Kras
, using
Rag1-Cre,
gave rise to CNS haemangioblastoma in the cortex and cerebellum in mice that present with highly vascular tumours with stromal cells similar to...
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Full title
A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5359595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5359595
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep44899
