Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Maternally inherited 15q11-13 chromosomal triplications cause a frequent and highly penetrant type of autism linked to increased gene dosages of
UBE3A
, which encodes a ubiquitin ligase with transcriptional co-regulatory functions. Here, using
in vivo
mouse genetics, we show that increasing UBE3A in the nucleus downregulates the glutama...
Alternative Titles
Full title
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5364052
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5364052
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21678
