PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcriptio...
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Transcription complexes that assemble at the HIV-1 promoter efficiently initiate transcription but generate paused RNA polymerase II downstream from the start site. The virally encoded Tat protein hijacks positive transcription elongation factor b (P-TEFb) to phosphorylate and activate this paused polymerase. In addition, Tat undergoes a series of...
Alternative Titles
Full title
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5366948
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5366948
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep45394
