Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells
Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
Clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 enables us to generate targeted sequence changes in the genomes of cells and organisms. However, off-target effects have been a persistent problem hampering the development of therapeutics based on CRISPR/Cas9 and potentially confounding research results. Efforts to improve Cas9 spec...
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Full title
Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5368403
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5368403
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1016/j.ymthe.2016.11.007
