Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis...
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/− mouse model
About this item
Full title
Author / Creator
Chapeau, Emilie A. , Gembarska, Agnieszka , Durand, Eric Y. , Mandon, Emeline , Estadieu, Claire , Romanet, Vincent , Wiesmann, Marion , Tiedt, Ralph , Lehar, Joseph , deWeck, Antoine , Rad, Roland , Barys, Louise , Jeay, Sebastien , Ferretti, Stephane , Kauffmann, Audrey , Sutter, Esther , Grevot, Armelle , Moulin, Pierre , Murakami, Masato , Sellers, William R. , Hofmann, Francesco and Jensen, Michael Rugaard
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Inhibitors of double minute 2 protein (MDM2)–tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the TP53 gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent CDKN2A deletion in human cancer that, through inactivation of p14ARF, activates MDM2 protein, which in t...
Alternative Titles
Full title
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/− mouse model
Authors, Artists and Contributors
Author / Creator
Gembarska, Agnieszka
Durand, Eric Y.
Mandon, Emeline
Estadieu, Claire
Romanet, Vincent
Wiesmann, Marion
Tiedt, Ralph
Lehar, Joseph
deWeck, Antoine
Rad, Roland
Barys, Louise
Jeay, Sebastien
Ferretti, Stephane
Kauffmann, Audrey
Sutter, Esther
Grevot, Armelle
Moulin, Pierre
Murakami, Masato
Sellers, William R.
Hofmann, Francesco
Jensen, Michael Rugaard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373361
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373361
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1620262114
