Laminar flow downregulates Notch activity to promote lymphatic sprouting
Laminar flow downregulates Notch activity to promote lymphatic sprouting
About this item
Full title
Author / Creator
Choi, Dongwon , Park, Eunkyung , Jung, Eunson , Seong, Young Jin , Yoo, Jaehyuk , Lee, Esak , Hong, Mingu , Lee, Sunju , Ishida, Hiroaki , Burford, James , Peti-Peterdi, Janos , Adams, Ralf H. , Srikanth, Sonal , Gwack, Yousang , Chen, Christopher S. , Vogel, Hans J. , Koh, Chester J. , Wong, Alex K. and Hong, Young-Kwon
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional drainage causes increased fluid flow that triggers lymphatic expansion, which is conceptually similar to hypoxia-triggered angiogenesis. Here, we have identified a mechanotransduction pathway that translates laminar flow-induced shear stress to activat...
Alternative Titles
Full title
Laminar flow downregulates Notch activity to promote lymphatic sprouting
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373895
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373895
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI87442
