Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
About this item
Full title
Author / Creator
Compagno, Mara , Wang, Qi , Pighi, Chiara , Cheong, Taek-Chin , Meng, Fei-Long , Poggio, Teresa , Yeap, Leng-Siew , Karaca, Elif , Blasco, Rafael B. , Langellotto, Fernanda , Ambrogio, Chiara , Voena, Claudia , Wiestner, Adrian , Kasar, Siddha N. , Brown, Jennifer R. , Sun, Jing , Wu, Catherine J. , Gostissa, Monica , Alt, Frederick W. and Chiarle, Roberto
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
PI3Kδ controls the expression of the recombinogenic enzyme AID; excessive AID activity caused by PI3Kδ inhibition can induce genomic instability in leukaemia and lymphoma cells, as well as in patients with chronic lymphocytic leukaemia treated with PI3Kδ inhibitors.
Unwanted DNA effects of cancer drugs
The phosphatidylinositol 3-kinase δ (PI3...
Alternative Titles
Full title
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
Authors, Artists and Contributors
Author / Creator
Wang, Qi
Pighi, Chiara
Cheong, Taek-Chin
Meng, Fei-Long
Poggio, Teresa
Yeap, Leng-Siew
Karaca, Elif
Blasco, Rafael B.
Langellotto, Fernanda
Ambrogio, Chiara
Voena, Claudia
Wiestner, Adrian
Kasar, Siddha N.
Brown, Jennifer R.
Sun, Jing
Wu, Catherine J.
Gostissa, Monica
Alt, Frederick W.
Chiarle, Roberto
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5382874
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5382874
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21406
