‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain. The cleavage relieves the intramolecular inhibition on the gasdermin-N domain, which then moves...
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Full title
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5384029
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5384029
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2017.24
