Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell d...
Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Upregulation of Smad7, an inhibitor of transforming growth factor-
β
1 (TGF-
β
1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of the cell cycle. These findings occ...
Alternative Titles
Full title
Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5386514
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5386514
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2017.103
