Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
About this item
Full title
Author / Creator
Pyzik, Michal , Rath, Timo , Kuo, Timothy T. , Win, Sanda , Baker, Kristi , Hubbard, Jonathan J. , Grenha, Rosa , Gandhi, Amit , Krämer, Thomas D. , Mezo, Adam R. , Taylor, Zachary S. , McDonnell, Kevin , Nienaber, Vicki , Andersen, Jan Terje , Mizoguchi, Atsushi , Blumberg, Laurence , Purohit, Shalaka , Jones, Susan D. , Christianson, Greg , Lencer, Wayne I. , Sandlie, Inger , Kaplowitz, Neil , Roopenian, Derry C. , Blumberg, Richard S. and Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective mechanism derives from FcRn binding to IgG in the weakly acidic environment contained within endosomes of hematopoietic and parenchy...
Alternative Titles
Full title
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Authors, Artists and Contributors
Author / Creator
Rath, Timo
Kuo, Timothy T.
Win, Sanda
Baker, Kristi
Hubbard, Jonathan J.
Grenha, Rosa
Gandhi, Amit
Krämer, Thomas D.
Mezo, Adam R.
Taylor, Zachary S.
McDonnell, Kevin
Nienaber, Vicki
Andersen, Jan Terje
Mizoguchi, Atsushi
Blumberg, Laurence
Purohit, Shalaka
Jones, Susan D.
Christianson, Greg
Lencer, Wayne I.
Sandlie, Inger
Kaplowitz, Neil
Roopenian, Derry C.
Blumberg, Richard S.
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5389309
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5389309
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1618291114
