Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorde...
Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Rett syndrome (RTT) is an X-linked neurological disorder caused by mutations in the methyl-CpG–binding protein 2 (MeCP2) gene. The majority of RTT missense mutations disrupt the interaction of the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator of retinoic acid and thyroid receptors (SMRT) corepressor complex. Here, we...
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Full title
Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5402415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5402415
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1700731114
