PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
About this item
Full title
Author / Creator
Ilic, Nina , Birsoy, Kıvanç , Aguirre, Andrew J. , Kory, Nora , Pacold, Michael E. , Singh, Shambhavi , Moody, Susan E. , DeAngelo, Joseph D. , Spardy, Nicole A. , Freinkman, Elizaveta , Weir, Barbara A. , Tsherniak, Aviad , Cowley, Glenn S. , Root, David E. , Asara, John M. , Vazquez, Francisca , Widlund, Hans R. , Sabatini, David M. and Hahn, William C.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large number of genomically annotated cancer cell lines....
Alternative Titles
Full title
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
Authors, Artists and Contributors
Author / Creator
Birsoy, Kıvanç
Aguirre, Andrew J.
Kory, Nora
Pacold, Michael E.
Singh, Shambhavi
Moody, Susan E.
DeAngelo, Joseph D.
Spardy, Nicole A.
Freinkman, Elizaveta
Weir, Barbara A.
Tsherniak, Aviad
Cowley, Glenn S.
Root, David E.
Asara, John M.
Vazquez, Francisca
Widlund, Hans R.
Sabatini, David M.
Hahn, William C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5410781
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5410781
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1617922114
