Polyglutamine tracts regulate beclin 1-dependent autophagy
Polyglutamine tracts regulate beclin 1-dependent autophagy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.
Protein tracts regulate autophagy
Expanded polyglutamine (polyQ) tracts in different proteins are a common feature of many neurodegenerative diseases. M...
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Full title
Polyglutamine tracts regulate beclin 1-dependent autophagy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5420314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5420314
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22078
