Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy
About this item
Full title
Author / Creator
Walker, Lauren Elizabeth , Frigerio, Federica , Ravizza, Teresa , Ricci, Emanuele , Tse, Karen , Jenkins, Rosalind E. , Sills, Graeme John , Jorgensen, Andrea , Porcu, Luca , Thippeswamy, Thimmasettappa , Alapirtti, Tiina , Peltola, Jukka , Brodie, Martin J. , Park, Brian Kevin , Marson, Anthony Guy , Antoine, Daniel James , Vezzani, Annamaria and Pirmohamed, Munir
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis is a key initiator of neuroinflammation following epileptogenic injuries, and its activation co...
Alternative Titles
Full title
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy
Authors, Artists and Contributors
Author / Creator
Frigerio, Federica
Ravizza, Teresa
Ricci, Emanuele
Tse, Karen
Jenkins, Rosalind E.
Sills, Graeme John
Jorgensen, Andrea
Porcu, Luca
Thippeswamy, Thimmasettappa
Alapirtti, Tiina
Peltola, Jukka
Brodie, Martin J.
Park, Brian Kevin
Marson, Anthony Guy
Antoine, Daniel James
Vezzani, Annamaria
Pirmohamed, Munir
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5451237
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5451237
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI92001
