Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblast...
Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma
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United States: John Wiley & Sons, Inc
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Language
English
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United States: John Wiley & Sons, Inc
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Catechol‐O‐methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O‐methylation. Tolcapone, a drug commonly used in the treatment of Parkinson's disease, is a potent inhibitor of COMT and previous studies indicate that Tolcapone increases the bioavailability of dopamine in cells. In this study, we demonstrate th...
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Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5463066
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5463066
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ISSN
2045-7634
E-ISSN
2045-7634
DOI
10.1002/cam4.1065
