Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gramnegative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their...
Alternative Titles
Full title
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465892
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465892
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1700721114
