Embryonic transcription factor SOX9 drives breast cancer endocrine resistance
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance
About this item
Full title
Author / Creator
Jeselsohn, Rinath , Cornwell, MacIntosh , Pun, Matthew , Buchwalter, Gilles , Nguyen, Mai , Bango, Clyde , Huang, Ying , Kuang, Yanan , Paweletz, Cloud , Fu, Xiaoyong , Nardone, Agostina , De Angelis, Carmine , Detre, Simone , Dodson, Andrew , Mohammed, Hisham , Carroll, Jason S. , Bowden, Michaela , Rao, Prakash , Long, Henry W. , Li, Fugen , Dowsett, Mitchell , Schiff, Rachel and Brown, Myles
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The estrogen receptor (ER) drives the growth of most luminal breast cancers and is the primary target of endocrine therapy. Although ER blockade with drugs such as tamoxifen is very effective, a major clinical limitation is the development of endocrine resistance especially in the setting of metastatic disease. Preclinical and clinical observations...
Alternative Titles
Full title
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance
Authors, Artists and Contributors
Author / Creator
Cornwell, MacIntosh
Pun, Matthew
Buchwalter, Gilles
Nguyen, Mai
Bango, Clyde
Huang, Ying
Kuang, Yanan
Paweletz, Cloud
Fu, Xiaoyong
Nardone, Agostina
De Angelis, Carmine
Detre, Simone
Dodson, Andrew
Mohammed, Hisham
Carroll, Jason S.
Bowden, Michaela
Rao, Prakash
Long, Henry W.
Li, Fugen
Dowsett, Mitchell
Schiff, Rachel
Brown, Myles
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465894
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465894
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1620993114
