CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
About this item
Full title
Author / Creator
Kim, Jiyeon , Hu, Zeping , Cai, Ling , Li, Kailong , Choi, Eunhee , Faubert, Brandon , Bezwada, Divya , Rodriguez-Canales, Jaime , Villalobos, Pamela , Lin, Yu-Fen , Ni, Min , Huffman, Kenneth E. , Girard, Luc , Byers, Lauren A. , Unsal-Kacmaz, Keziban , Peña, Christopher G. , Heymach, John V. , Wauters, Els , Vansteenkiste, Johan , Castrillon, Diego H. , Chen, Benjamin P. C. , Wistuba, Ignacio , Lambrechts, Diether , Xu, Jian , Minna, John D. and DeBerardinis, Ralph J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In human cell lines with mutant
KRAS
and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA damage and cell death as a result of pyrimidine depletion rather than ammonia toxicity.
CPS1-mediated DNA synthesis in lung cancer
Cancer cells have an altered cellular metabolism to...
Alternative Titles
Full title
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Authors, Artists and Contributors
Author / Creator
Hu, Zeping
Cai, Ling
Li, Kailong
Choi, Eunhee
Faubert, Brandon
Bezwada, Divya
Rodriguez-Canales, Jaime
Villalobos, Pamela
Lin, Yu-Fen
Ni, Min
Huffman, Kenneth E.
Girard, Luc
Byers, Lauren A.
Unsal-Kacmaz, Keziban
Peña, Christopher G.
Heymach, John V.
Wauters, Els
Vansteenkiste, Johan
Castrillon, Diego H.
Chen, Benjamin P. C.
Wistuba, Ignacio
Lambrechts, Diether
Xu, Jian
Minna, John D.
DeBerardinis, Ralph J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5472349
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5472349
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22359
