JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
About this item
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Author / Creator
Zhou, C , Martinez, E , Di Marcantonio, D , Solanki-Patel, N , Aghayev, T , Peri, S , Ferraro, F , Skorski, T , Scholl, C , Fröhling, S , Balachandran, S , Wiest, D L and Sykes, S M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The transcription factor JUN is frequently overexpressed in multiple genetic subtypes of acute myeloid leukemia (AML); however, the functional role of JUN in AML is not well defined. Here we report that short hairpin RNA (shRNA)-mediated inhibition of JUN decreases AML cell survival and propagation
in vivo
. By performing RNA sequencing analy...
Alternative Titles
Full title
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5473421
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5473421
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2016.329
