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Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance...

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5474817

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

About this item

Full title

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2017-06, Vol.114 (24), p.6358-6363

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Brain glycogen stored in astrocytes provides lactate as an energy source to neurons through monocarboxylate transporters (MCTs) to maintain neuronal functions such as hippocampus-regulated memory formation. Although prolonged exhaustive exercise decreases brain glycogen, the role of this decrease and lactate transport in the exercising brain remain...

Alternative Titles

Full title

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5474817

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5474817

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1702739114

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