Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Structural and functional characterization of tetracycline-inactivating enzymes reveals that inhibitors act by locking the enzyme in an unproductive state by restricting substrate-driven conformational dynamics that are important for catalysis.
Although tetracyclines are an important class of antibiotics for use in agriculture and the clinic, th...
Alternative Titles
Full title
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5478473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5478473
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2376
