From Krebs to clinic: glutamine metabolism to cancer therapy
From Krebs to clinic: glutamine metabolism to cancer therapy
About this item
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Key Points
Cancer cells show increased consumption of and dependence on glutamine.
Glutamine metabolism fuels the tricarboxylic acid (TCA) cycle, nucleotide and fatty acid biosynthesis, and redox balance in cancer cells.
Glutamine activates mTOR signalling, suppresses endoplasmic reticulum stress and promotes protein synthesis.
Cancer c...
Alternative Titles
Full title
From Krebs to clinic: glutamine metabolism to cancer therapy
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5484415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5484415
Other Identifiers
ISSN
1474-175X,1474-1768
E-ISSN
1474-1768
DOI
10.1038/nrc.2016.71
