The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
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Author / Creator
Wang, Haizhen , Nicolay, Brandon N. , Chick, Joel M. , Gao, Xueliang , Geng, Yan , Ren, Hong , Gao, Hui , Yang, Guizhi , Williams, Juliet A. , Suski, Jan M. , Keibler, Mark A. , Sicinska, Ewa , Gerdemann, Ulrike , Haining, W. Nicholas , Roberts, Thomas M. , Polyak, Kornelia , Gygi, Steven P. , Dyson, Nicholas J. and Sicinski, Piotr
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.
Cancer cell survival by cyclin D3–CDK6 metabolism
Cyclin–CDK complexes are commonly amplified in cancer and promote cell cycle progression. Inhibi...
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Full title
The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5516959
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5516959
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22797
