TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implicatio...
TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
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Publisher
England: BMJ Publishing Group LTD
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Language
English
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Publisher
England: BMJ Publishing Group LTD
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ObjectiveWe investigated the mutational landscape of mammalian target of rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, aiming to evaluate and delineate mutation-dependent mechanism of mTOR hyperactivation in hepatocarcinogenesis.DesignWe performed next-generation sequencing on human HCC samples...
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TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5530480
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5530480
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2016-312734
