RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
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Author / Creator
Publisher
England: BMJ Publishing Group LTD
Journal title
Language
English
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Publisher
England: BMJ Publishing Group LTD
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Contents
ObjectiveThe gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, leading to enhanced expression of these R-spondin gene...
Alternative Titles
Full title
RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5532462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5532462
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2016-311606
