Tissue-specific mutation accumulation in human adult stem cells during life
Tissue-specific mutation accumulation in human adult stem cells during life
About this item
Full title
Author / Creator
Blokzijl, Francis , de Ligt, Joep , Jager, Myrthe , Sasselli, Valentina , Roerink, Sophie , Sasaki, Nobuo , Huch, Meritxell , Boymans, Sander , Kuijk, Ewart , Prins, Pjotr , Nijman, Isaac J. , Martincorena, Inigo , Mokry, Michal , Wiegerinck, Caroline L. , Middendorp, Sabine , Sato, Toshiro , Schwank, Gerald , Nieuwenhuis, Edward E. S. , Verstegen, Monique M. A. , van der Laan, Luc J. W. , de Jonge, Jeroen , IJzermans, Jan N. M. , Vries, Robert G. , van de Wetering, Marc , Stratton, Michael R. , Clevers, Hans , Cuppen, Edwin and van Boxtel, Ruben
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly among these tissues.
Accumulated mutations in adult stem cells
Accumulation of mutations in human adult stem cells in the course of a lifetime has been associated with increase in canc...
Alternative Titles
Full title
Tissue-specific mutation accumulation in human adult stem cells during life
Authors, Artists and Contributors
Author / Creator
de Ligt, Joep
Jager, Myrthe
Sasselli, Valentina
Roerink, Sophie
Sasaki, Nobuo
Huch, Meritxell
Boymans, Sander
Kuijk, Ewart
Prins, Pjotr
Nijman, Isaac J.
Martincorena, Inigo
Mokry, Michal
Wiegerinck, Caroline L.
Middendorp, Sabine
Sato, Toshiro
Schwank, Gerald
Nieuwenhuis, Edward E. S.
Verstegen, Monique M. A.
van der Laan, Luc J. W.
de Jonge, Jeroen
IJzermans, Jan N. M.
Vries, Robert G.
van de Wetering, Marc
Stratton, Michael R.
Clevers, Hans
Cuppen, Edwin
van Boxtel, Ruben
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536223
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536223
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature19768
