Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention of exosomes, compared to liposomes, in the circulation of mice is likely due to CD47-mediated p...
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Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5538883
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5538883
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature22341
