Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
ClC‐7 is a chloride channel of late endosomes and lysosomes. In osteoclasts, it may cooperate with H
+
‐ATPases in acidifying the resorption lacuna. In mice and man, loss of ClC‐7 or the H
+
‐ATPase a3 subunit causes osteopetrosis, a disease characterized by defective bone resorption. We show that ClC‐7 knockout mice additionally displa...
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Full title
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_554126
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_554126
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7600576
